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PIK-75

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Cat.No：IP1460 Solarbio

CAS：372196-77-5

Molecular Formula：C₁₆H₁₅BrClN₅O₄S

Molecular Weight：488.74

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	372196-77-5
Name	PIK-75 hydrochloride
Molecular Formula	C₁₆H₁₅BrClN₅O₄S
Molecular Weight	488.74
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD01321139
SMILES	BrC(C=C1)=CN2C1=NC=C2/C=N/N(S(=O)(C3=C(C=CC([N+]([O-])=O)=C3)C)=O)C.[H]Cl
Target Point	DNA-PK
Passage	DNA Damage/DNA Repair
Background	PIK-75 is a DNA-PK and PI3K inhibitor.
Biological Activity	PIK-75 是一种 DNA-PK 和 PI3K 抑制剂，抑制 DNA-PK，p110α 和 p110γ，IC50 分别为 2, 5.8 和 76 nM。PIK-75 抑制 p110α 效果比抑制 p110β (IC50=1.3 μM) 高 200 多倍。[1-3]
IC50	DNA-PK:2nM;p110β:1.3μM;hsVPS34:2.6μM;PI3KC2β:1μM;mTORC1:1μM;ATM:2.3μM [1-3]
Data Literature Source	[1]. Knight ZA，et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Zheng Z，et al. Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition. Mol Pharmacol. 2011 Oct;80(4):657-64. [3]. Duong HQ，et al. Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int J Oncol. 2014 Mar;44(3):959-69.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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