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PFI-1

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Cat.No：IP1450 Solarbio

CAS：1403764-72-6

Molecular Formula：C₁₆H₁₇N₃O₄S

Molecular Weight：347.39

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥96%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1403764-72-6
Name	PFI-1
Molecular Formula	C₁₆H₁₇N₃O₄S
Molecular Weight	347.39
Solubility	Soluble in DMSO
Purity	≥96%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00235883
SMILES	O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O
Target Point	Epigenetic Reader Domain
Passage	Epigenetics
Background	PFI-1 is a potent BET inhibitor that can effectively inhibit BRD4.
Biological Activity	PFI-1 是一种有效的 BET 抑制剂，能够有效抑制 BRD4，IC50 值为 0.22 μM。[1-4]
IC50	0.22μM(BRD4)[1-4]
Data Literature Source	[1]. Picaud S，et al. PFI-1，a Highly Selective Protein Interaction Inhibitor，Targeting BET Bromodomains. Cancer Res. 2013 May 21. [Epub ahead of print] [2]. Fish PV，et al. Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012 Nov 26;55(22):9831-7. [3]. Cheng Z，et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res. 2013 Apr 1;19(7):1748-59. [4]. Kate E Lines，et al. Epigenetic modifiers reduce proliferation of human neuroendocrine tumour cell lines. Endocrine Abstracts (2013) 31 P149
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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