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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Fludarabine phosphateCAS：75607-67-9
Molecular Formula：C10H13FN5O7P
Molecular Weight：365.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 75607-67-9 |
| Name | Fludarabine phosphate |
| Molecular Formula | C10H13FN5O7P |
| Molecular Weight | 365.21 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 616-242-0 |
| MDL | MFCD00866418 |
| SMILES | NC1=C2C(N([C@H]3[C@@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O3)C=N2)=NC(F)=N1 |
| InChIKey | GIUYCYHIANZCFB-FJFJXFQQSA-N |
| InChI | InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1 |
| PubChem CID | 30751 |
| Target Point | DNA/RNA Synthesis inhibitor |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Fludarabine phosphate is an analog of adenosine and deoxyadenosine that competes with dATP for incorporation into DNA, resulting in a block in DNA synthesis. |
| Biological Activity | Fludarabine phosphate 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，导致 DNA 合成受阻。[1-2] |
| Data Literature Source | [1]. Sorscher EJ，et al. In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase. Cancer Chemother Pharmacol. 2012 Aug;70(2):321-9. [2]. Kikuchi E，et al. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug，fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Th |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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