Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Cladribine

Cladribine

Manual Download

Cat.No：IC1690 Solarbio

CAS：4291-63-8

Molecular Formula：C₁₀H₁₂ClN₅O₃

Molecular Weight：285.69

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥99%

Appearance：White to off-white Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	4291-63-8
Name	Cladribine
Molecular Formula	C₁₀H₁₂ClN₅O₃
Molecular Weight	285.69
Solubility	Soluble in DMSO
Purity	HPLC≥99%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 224-427-9
MDL	MFCD00153939
SMILES	OC[C@@H]1[C@H](C[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O1)O
InChIKey	PTOAARAWEBMLNO-KVQBGUIXSA-N
InChI	InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
PubChem CID	20279
Target Point	Adenosine Deaminase
Passage	Metabolic Enzyme&Protease
Background	Cladribine is an adenosine deaminase inhibitor.
Biological Activity	Cladribine is a well-known purine nucleoside analog with particular activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL).[1]
IC50	Adenosine deaminase(MM1.S cells): 0.18μM;Adenosine deaminase(RPMI8226 cells): 0.75μM;Adenosine deaminase(U266 cells): 2.43μM [1]
Data Literature Source	[1]. Ma J，Wang S，Zhao M，Deng XS，Lee CK，Yu XD，Liu B. Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. [2]. Klein LC，Yeung PK，Berman JN. Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model. Biomarkers. 2009 Dec;14(8):554-9.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.