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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > VismodegibCAS：879085-55-9
Molecular Formula：C19H14Cl2N2O3S
Molecular Weight：421.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to yellow Solid
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| CAS | 879085-55-9 |
| Name | Vismodegib |
| Molecular Formula | C19H14Cl2N2O3S |
| Molecular Weight | 421.3 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 806-752-3 |
| MDL | MFCD12407408 |
| SMILES | O=C(C1=CC=C(C=C1Cl)S(=O)(C)=O)NC2=CC=C(C(C3=NC=CC=C3)=C2)Cl |
| Target Point | Hedgehog |
| Passage | Hedgehog;Stem Cells |
| Background | Vismodegib is a hedgehog inhibitor; simultaneously inhibits the activity of P-gp and ABCG2. |
| Biological Activity | Vismodegib 是一种可口服的 hedgehog 抑制剂，IC50 值为 3 nM；同时可抑制 P-gp 和 ABCG2 的活性，IC50 值分别为 3.0 μM 和 1.4 μM。Vismodegib是一种新型小分子HPI。Vismodegib是一种ABCG2抑制剂 [1-6] |
| Data Literature Source | [1]. Scales SJ，et al. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009，30(6)，303-312. [2]. Zhang Y，et al. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia. 2009，11(1)，96-101. [3]. Tian F，et al. The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. Anticancer Res. 2012，32(1)，89-94. [4]. Wong H，et al. Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin Cancer Res. 2011，17(14)，4682-4692. [5]. Elhenawy AA，et al. Possible antifibrotic effect of GDC-0449 (Vismodegib)，a hedgehog-pathway inhibitor，in mice model of Schistosoma-induced liver fibrosis. Parasitol Int. 2017 Oct;66(5):545-554. [6]. Ma W，et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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