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Iniparib

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Cat.No：II0700 Solarbio

CAS：160003-66-7

Molecular Formula：C₇H₅IN₂O₃

Molecular Weight：292.03

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	160003-66-7
Name	Iniparib
Molecular Formula	C₇H₅IN₂O₃
Molecular Weight	292.03
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 685-396-9
MDL	MFCD11110639
SMILES	O=C(C1=CC=C(C([N+]([O-])=O)=C1)I)N
Target Point	PARP
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	Iniparib/BSI-201 is an irreversible PARP1 inhibitor for the study of triple-negative breast cancer.
Biological Activity	Iniparib是一种不可逆的 PARP1 抑制剂，可用于三阴性乳腺癌的研究。Iniparib非选择性地修饰肿瘤细胞中含半胱氨酸的蛋白质。[1-3]
Data Literature Source	[1]. Liu X，et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18(2):510-23. [2]. Ma W，et al. Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6590-5. [3]. Yin S，et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12(8):e0183578.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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