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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > GSK429286ACAS：864082-47-3
Molecular Formula：C21H16F4N4O2
Molecular Weight：432.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 864082-47-3 |
| Name | GSK429286A |
| Molecular Formula | C21H16F4N4O2 |
| Molecular Weight | 432.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16618404 |
| SMILES | O=C(C(C(C1=CC=C(C(F)(F)F)C=C1)C2)=C(C)NC2=O)NC3=CC4=C(NN=C4)C=C3F |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | GSK429286A is a selective ROCK1 inhibitor. |
| Biological Activity | GSK429286A是选择性的 ROCK1 抑制剂, IC50 值为14 nM[1-2]。 |
| IC50 | ROCK1:14nM (IC50) RSK:780nM (IC50) p70S6K:1940nM (IC50) [1-2] |
| Data Literature Source | [1]. Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11; 50 (1) :6-9. [2]. Nichols RJ et al Substrate specificity and inhibitors of LRRK2， a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23; 424 (1) :47-60. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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