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Hesperadin

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Cat.No：IH0630 Solarbio

CAS：422513-13-1

Molecular Formula：C₂₉H₃₂N₄O₃S

Molecular Weight：516.65

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	422513-13-1
Name	Hesperadin
Molecular Formula	C₂₉H₃₂N₄O₃S
Molecular Weight	516.65
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 200-258-5
MDL	MFCD18074526
SMILES	O=C1NC2=CC=C(C=C2/C1=C(NC3=CC=C(C=C3)CN4CCCCC4)\C5=CC=CC=C5)NS(CC)(=O)=O
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Hesperadin is an ATP-competitive Aurora B inhibitor.
Biological Activity	Hesperadin是ATP竞争型的Aurora B 抑制剂，IC50值为250 nM。[1-3]
IC50	Aurora B:250nM(IC50)[1-3]
Data Literature Source	[1]. Hauf S，et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 2003 Apr 28;161(2):281-94. [2]. Hu Y，et al. Chemical Genomics Approach Leads to the Identification of Hesperadin，an Aurora B Kinase Inhibitor，as a Broad-Spectrum Influenza Antiviral. Int J Mol Sci. 2017 Sep 8;18(9). [3]. Ladygina NG，et al. Effect of the pharmacological agent hesperadin on breast and prostate tumor cultured cells. Biomed Khim. 2005 Mar-Apr;51(2):170-6.
Unit	Bottle
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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