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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > HMN-214CAS：173529-46-9
Molecular Formula：C22H20N2O5S
Molecular Weight：424.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 173529-46-9 |
| Name | HMN-214 |
| Molecular Formula | C22H20N2O5S |
| Molecular Weight | 424.47 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12756255 |
| SMILES | CC(N(C1=C(C=CC=C1)/C=C/C2=CC=N(C=C2)=O)S(C3=CC=C(C=C3)OC)(=O)=O)=O |
| Target Point | Polo-like Kinase (PLK) |
| Passage | Cell Cycle |
| Background | HMN-214 is a plk1 inhibitor. |
| Biological Activity | HMN-214 是一种 plk1 抑制剂，具有抗肿瘤活性。HMN-176显示出针对22种人肿瘤细胞系的有效活性，平均IC50为118 nM。 [1-4] |
| Data Literature Source | [1]. Takagi M，et al. In vivo antitumor activity of a novel sulfonamide，HMN-214，against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite，HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99. [2]. Garland LL，et al. A phase I pharmacokinetic study of HMN-214，a novel oral stilbene derivative with polo-like kinase-1-interacting properties，in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9. [3]. Tanaka H，et al. HMN-176，an active metabolite of the synthetic antitumor agent HMN-214，restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7. [4]. Christensen MD，et al. Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression. J Control Release. 2015 Apr 28;204:20-9. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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