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Pimasertib

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Cat.No：IP1590 Solarbio

CAS：1236699-92-5

Molecular Formula：C₁₅H₁₅FIN₃O₃

Molecular Weight：431.2

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	1236699-92-5
Name	Pimasertib
Molecular Formula	C₁₅H₁₅FIN₃O₃
Molecular Weight	431.2
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00015027
SMILES	FC1=C(C=CC(I)=C1)NC2=CN=CC=C2C(NC[C@@H](CO)O)=O
Target Point	MEK
Passage	MAPK
Background	Pimasertib/AS-703026 is a potent, selective, and ATP-noncompetitive allosteric inhibitor of MEK1/2, primarily for cancer research.
Biological Activity	Pimasertib (AS703026) 是一种高效，具有选择性，ATP 非竞争性的 MEK1/2 别构抑制剂，主要用于癌症研究。[1-3]
Data Literature Source	[1]. Kim K，et al. Blockade of the MEK/ERK signalling cascade by AS703026，a novel selective MEK1/2 inhibitor，induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol，2010，149(4)，537-549. [2]. Yoon J，et al. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res，2011，71(2)，445-453. [3]. Park SJ，et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8.
Unit	Bottle
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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