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Ponatinib

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Cat.No：IP1600 Solarbio

CAS：943319-70-8

Molecular Formula：C₂₉H₂₇F₃N₆O

Molecular Weight：532.57

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	943319-70-8
Name	Ponatinib
Molecular Formula	C₂₉H₂₇F₃N₆O
Molecular Weight	532.57
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1308068-626-2
MDL	MFCD17215203
SMILES	CC1=C(C=C(C=C1)C(NC2=CC(C(F)(F)F)=C(C=C2)CN3CCN(CC3)C)=O)C#CC4=CN=C5N4N=CC=C5
Target Point	Bcr-Abl;PDGFRα;VEGFR2;FGFR1;Src
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	It is a potent, multi-target kinase inhibitor that inhibits Abl, PDGFRα, VEGFR2, FGFR1 and Src.
Biological Activity	Ponatinib是一种有效的，可口服的多靶点激酶抑制剂，抑制Abl，PDGFRα，VEGFR2，FGFR1 和 Src 的 IC50 分别为0.37 nM， 1.1 nM，1.5 nM，2.2 nM和5.4 nM。[1-3]
IC50	VEGFR2:1.5nM;PDGFRα:1.1nM;FGFR1:2.2nM;c-Kit:12.5nM [1-3]
Data Literature Source	[1]. O'Hare T，et al. AP24534，a pan-BCR-ABL inhibitor for chronic myeloid leukemia，potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell，2009，16(5)，401-412. [2]. Gozgit JM，et al. Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther，2011，10(6)，1028-1035. [3]. Uchida T，et al. Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis. Exp Hematol. 2014 May;42(5):369-379.e3.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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