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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > QuizartinibCAS：950769-58-1
Molecular Formula：C29H32N6O4S
Molecular Weight：560.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 950769-58-1 |
| Name | Quizartinib |
| Molecular Formula | C29H32N6O4S |
| Molecular Weight | 560.68 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18074524 |
| SMILES | O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C=C2)C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3 |
| Target Point | FLT3 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Quizartinib is a potent Flt3 tyrosine kinase inhibitor. |
| Biological Activity | Quizartinib (AC220) 是一种有效的 Flt3 酪氨酸激酶抑制剂，Kd值为1.6±0.7 nM。[1-2] |
| Data Literature Source | [1]. Zarrinkar PP，et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood，2009，114(14)，2984-2992. [2]. Puissant A，et al. SYK is a critical regulator of FLT3 in acute myeloid leukemia. Cancer Cell. 2014 Feb 10;25(2):226-42. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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