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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > PLX-4720CAS：918505-84-7
Molecular Formula：C17H14ClF2N3O3S
Molecular Weight：413.83
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 918505-84-7 |
| Name | PLX-4720 |
| Molecular Formula | C17H14ClF2N3O3S |
| Molecular Weight | 413.83 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14635203 |
| SMILES | O=S(NC1=CC=C(C(C(C2=CNC3=NC=C(C=C23)Cl)=O)=C1F)F)(CCC)=O |
| Target Point | Raf |
| Passage | MAPK |
| Background | PLX-4720 is a potent and selective inhibitor of B-RafV600E. |
| Biological Activity | PLX-4720 是一种有效的，选择性的 B-RafV600E 抑制剂，IC50 值为 13 nM；与对 c-Raf-1 的选择性相同，是野生型 B-Raf 选择性的 10 倍。[1-4] |
| Data Literature Source | [1]. Tsai J，et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A，2008，105(8)，3041-3046. [2]. Paraiso KH，et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res，2011，71(7)，2750-2760. [3]. Nucera C，et al. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A，2010，107(23)，10649-10654. [4]. Rizzolio S，et al. Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies. J Clin Invest. 2018 Aug 31;128(9):3976-3990. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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