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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > MK-8245CAS：1030612-90-8
Molecular Formula：C17H16BrFN6O4
Molecular Weight：467.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1030612-90-8 |
| Name | MK-8245 |
| Molecular Formula | C17H16BrFN6O4 |
| Molecular Weight | 467.26 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20039622 |
| SMILES | O=C(CN1N=C(N=N1)C2=CC(N3CCC(CC3)OC4=CC(F)=CC=C4Br)=NO2)O |
| Target Point | Stearoyl-CoA Desaturase (SCD) |
| Passage | Metabolic Enzyme&Protease |
| Background | MK-8245 is a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor. |
| Biological Activity | MK-8245 is a potent， liver-targeted stearoyl-CoA desaturase (SCD) inhibitor， with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1， with antidiabetic and antidyslipidemic efficacy[1]. |
| IC50 | IC50: 1nM(human SCD1);3nM(rat SCD1);3nM(mouse SCD1)[1] |
| Data Literature Source | [1]. Oballa RM，et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.J Med Chem. 2011 Jul 28;54(14):5082-96. Epub 2011 Jun 28. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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