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Lenvatinib

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Cat.No：IL0770 Solarbio

CAS：417716-92-8

Molecular Formula：C₂₁H₁₉ClN₄O₄

Molecular Weight：426.85

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	417716-92-8
Name	Lenvatinib
Molecular Formula	C₂₁H₁₉ClN₄O₄
Molecular Weight	426.85
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1592732-453-0
MDL	MFCD16038644
SMILES	O=C(N)C1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C(Cl)=C3)NC(NC4CC4)=O)OC
Target Point	VEGFR;PDGFRβ;FGFR1
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	Lenvatinib is a multi-targeted tyrosine kinase inhibitor.
Biological Activity	Lenvatinib是一种有口服活性的多靶点酪氨酸激酶抑制剂，抑制 VEGFR2(KDR) 和 VEGFR3(Flt-4) 的 IC50 分别为 4 和 5.2 nM。[1-3]
IC50	VEGFR2:4nM;VEGFR3:5.2nM [1-3]
Data Literature Source	[1]. Matsui J，et al. E7080，a novel inhibitor that targets multiple kinases，has potent antitumor activities against stem cell factor producing human small cell lung cancer H146，based on angiogenesis inhibition. Int J Cancer. 2008，122(3)，664-671. [2]. Matsui J，et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res. 2008，14(17)，545 [3]. Glen H，et al. E7080，a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion. BMC Cancer. 2011，11，309
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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