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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > DelanzomibCAS：847499-27-8
Molecular Formula：C21H28BN3O5
Molecular Weight：413.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 847499-27-8 |
| Name | Delanzomib |
| Molecular Formula | C21H28BN3O5 |
| Molecular Weight | 413.28 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251439 |
| SMILES | CC(C)C[C@@H](B(O)O)NC([C@@H](NC(C1=NC(C2=CC=CC=C2)=CC=C1)=O)[C@H](O)C)=O |
| Target Point | Proteasome |
| Passage | Metabolic Enzyme&Protease |
| Background | It is an orally active inhibitor of proteasome chymotrypsin-like activity, which can down-regulate nuclear NF-kappaB activity. |
| Biological Activity | Delanzomib (CEP-18770)是一种有效的，具有胰凝乳蛋白酶样活性的蛋白酶体抑制剂，IC50为3.8 nM，只最低限度地抑制蛋白酶体的胰蛋白酶和肽谷氨酰基活性。[1] |
| IC50 | Chymotrypsin-like proteasome:3.8nM [1] |
| Data Literature Source | [1] Piva R，et al. Blood. 2008，111(5)，2765-2775. [2] Sanchez E，et al. Br J Haematol. 2010，148(4)，569-581. [3] Berkers CR，et al. Nat Methods. 2005，2(5)，357-362. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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