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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > WZ4002CAS：1213269-23-8
Molecular Formula：C25H27ClN6O3
Molecular Weight：494.18
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1213269-23-8 |
| Name | WZ4002 |
| Molecular Formula | C25H27ClN6O3 |
| Molecular Weight | 494.18 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-141-6 |
| MDL | MFCD16621244 |
| SMILES | COC1=C(C=CC(N2CCN(CC2)C)=C1)NC3=NC=C(C(OC4=CC(NC(C=C)=O)=CC=C4)=N3)Cl |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | WZ4002 is a novel, potent, covalent/irreversible and mutation-selective EGFR inhibitor |
| Biological Activity | WZ4002是突变选择性的 EGFR 抑制剂；对EGFRL858R，EGFRL858R/T790M，EGFRE746_A750，EGFRE746_A750/T790M 的 IC50 值分别为2，8，3，2 nM。[1] |
| Data Literature Source | [1]. Zhou W，et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.Nature. 2009 Dec 24;462(7276):1070-4. |
| Unit | Bottle |
| Specification | 20mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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