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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > 2-MethoxyestradiolCAS：362-07-2
Molecular Formula：C19H26O3
Molecular Weight：302.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 362-07-2 |
| Name | 2-Methoxyestradiol |
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.41 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00010489 |
| SMILES | OC1=CC2=C([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC2)[H])[H])O)C)[H])C=C1OC |
| Target Point | Autophagy;Apoptosis;Microtubule/Tubulin |
| Passage | Autophagy;Apoptosis;Cytoskeleton |
| Background | 2-Methoxyestradiol is an angiogenesis inhibitor and apoptosis inducer with potent antitumor activity. 2-Methoxyestradiol can also destabilize microtubules. |
| Biological Activity | 2-Methoxyestradiol是血管生成抑制剂和凋亡诱导剂，具有有效的抗肿瘤活性。 2-Methoxyestradiol也可破坏微管的稳定。[1-4] |
| Data Literature Source | [1]. Kamath K，et al. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther. 2006 Sep;5(9):2225-33. [2]. Aquino-Gálvez A，et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016 Jan;35(1):577-83. [3]. Xu L，et al. 2-Methoxyestradiol Alleviates Experimental Autoimmune Uveitis by Inhibiting Lymphocytes Proliferation and T Cell Differentiation. Biomed Res Int. 2016;2016:7948345. [4]. Kang SH，et al. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res. 2006，66(24)，11991-11997 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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