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Danoprevir

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Cat.No：ID1080 Solarbio

CAS：850876-88-9

Molecular Formula：C₃₅H₄₆FN₅O₉S

Molecular Weight：731.83

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	850876-88-9
Name	Danoprevir
Molecular Formula	C₃₅H₄₆FN₅O₉S
Molecular Weight	731.83
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16038038
SMILES	O=S(NC([C@@]1(NC([C@]2([H])C[C@@H](OC(N3CC4=C(C3)C=CC=C4F)=O)CN2C5=O)=O)C[C@]1(/C=C/CCCCC[C@@H]5NC(OC(C)(C)C)=O)[H])=O)(C6CC6)=O
Target Point	HCV Protease
Passage	Metabolic Enzyme/Protease
Background	Danoprevir is a peptidomimetic inhibitor that inhibits HCV NS3/4A protease.
Biological Activity	Danoprevir 是一种模拟肽类抑制剂, 能够抑制 HCV NS3/4A protease, IC50 值为 0.2-3.5 nM[1-3]。
IC50	IC50: 0.2-3.5nM (NS3/4A protease) [1-3]
Data Literature Source	[1]. Imhof I， et al. Genotype differences in susceptibility and resistance development of hepatitis C virus to protease inhibitors telaprevir (VX-950) and danoprevir (ITMN-191) .Hepatology. 2011 Apr; 53 (4) :1090-9. [2]. Seiwert， Scott D.， et al. Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227) . Antimicrobial Agents and Chemotherapy (2008) ， 52 (12) ， 4432-4441. [3]. Bartels DJ， et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 2008 Sep 15; 198 (6) :800-7
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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