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CNF2024

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Cat.No：IC1790 Solarbio

CAS：848695-25-0

Molecular Formula：C₁₄H₁₅ClN₆O

Molecular Weight：318.77

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	848695-25-0
Name	CNF2024
Molecular Formula	C₁₄H₁₅ClN₆O
Molecular Weight	318.77
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 812-781-2
MDL	MFCD15528939
SMILES	ClC1=C2C(N(C=N2)CC3=C(C(OC)=C(C=N3)C)C)=NC(N)=N1
Target Point	HSP90
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	BIIB021 is an HSP90 inhibitor.
Biological Activity	BIIB021 是一种 HSP90 抑制剂，Ki 值和 EC50 值分别为 1.7 nM 和 38 nM[4]。
Data Literature Source	[1]. Lundgren，Karen.，et al. CNF2024，an orally available，fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular Cancer Therapeutics (2009)，8(4)，921-929. [2]. B ll B，et al. Heat shock protein 90 inhibitor CNF2024 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin Cancer Res. 2009 Aug 15;15(16):5108-16. [3]. Yin X，et al. CNF2024，a novel Hsp90 inhibitor，sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010 Mar 1;126(5):1216-25. [4]. Zhang H，et al. CNF2024，a synthetic Hsp90 inhibitor，has broad application against tumors with acquired multidrug resistance. Int J Cancer. 2010 Mar 1;126(5):1226-34.
Unit	Bottle
Specification	5mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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