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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > BicalutamideCAS：90357-06-5
Molecular Formula：C18H14F4N2O4S
Molecular Weight：430.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 90357-06-5 |
| Name | Bicalutamide |
| Molecular Formula | C18H14F4N2O4S |
| Molecular Weight | 430.37 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-001-8 |
| MDL | MFCD00869971 |
| SMILES | FC1=CC=C(S(=O)(CC(O)(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)C)=O)C=C1 |
| InChIKey | LKJPYSCBVHEWIU-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25) |
| PubChem CID | 2375 |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | Bicalutamide is a nonsteroidal androgen receptor inhibitor. |
| Biological Activity | Bicalutamide (ICI-176334) 是一种androgen receptor (AR)拮抗剂，在LNCaP/AR(cs)细胞系中IC50为0.16 μM。Bicalutamide 可诱导自噬。[1] |
| Data Literature Source | [1] Clegg NJ，et al. Cancer Res. 2012，72(6)，1494-1503. [2] Colquhoun AJ，et al. Prostate Cancer Prostatic Dis. 2012. [3] Squillace RM，et al. Int J Oncol. 2012. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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