{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BIBR 1532CAS：321674-73-1
Molecular Formula：C21H17NO3
Molecular Weight：331.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
Qty：
Size：
| CAS | 321674-73-1 |
| Name | BIBR 1532 |
| Molecular Formula | C21H17NO3 |
| Molecular Weight | 331.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11112195 |
| SMILES | O=C(O)C1=CC=CC=C1NC(/C=C(C2=CC=C3C=CC=CC3=C2)\C)=O |
| Target Point | Telomerase inhibitor |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | BIBR 1532 is a potent and selective noncompetitive inhibitor of telomerase. |
| Biological Activity | BIBR 1532 是一种有效的，选择性的 telomerase 非竞争性抑制剂，IC50 值为 100 nM[1-5]。 |
| IC50 | 100nM(telomerase)[1-5] |
| Data Literature Source | [1]. Pascolo E，et al. Mechanism of human telomerase inhibition by BIBR1532，a synthetic，non-nucleosidic drug candidate. J Biol Chem. 2002 May 3;277(18):15566-72. [2]. El-Daly H，et al. Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood. 2005 Feb 15;105(4):1742-9. [3]. Ward RJ，et al. Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol. 2005 Sep;68(3):779-86. [4]. R th A，et al. Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia. Leukemia. 2007 Dec;21(12):2456-62. [5]. Meng E，et al. Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells. Gynecol Oncol. 2012 Mar;124(3):598-605. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
