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Barasertib-HQPA

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Cat.No：IB0810 Solarbio

CAS：722544-51-6

Molecular Formula：C₂₆H₃₀FN₇O₃

Molecular Weight：507.56

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	722544-51-6
Name	Barasertib-HQPA
Molecular Formula	C₂₆H₃₀FN₇O₃
Molecular Weight	507.56
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17392583
SMILES	O=C(CC1=NNC(NC2=C3C=CC(OCCCN(CCO)CC)=CC3=NC=N2)=C1)NC4=CC=CC(F)=C4
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Barasertib-HQPA is a highly selective Aurora B inhibitor.
Biological Activity	AZD1152-HQPA 是一种高度选择性的 Aurora B 抑制剂, IC50 值为 0.37 nM, 对 Aurora B 的选择性是 Aurora A 的 3700 倍[1-3]。
IC50	Aurora B:0.37nM (IC50) [1-3]
Data Literature Source	[1]. Wilkinson RW， et al. AZD1152， a selective inhibitor of Aurora B kinase， inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15; 13 (12) :3682-8. [2]. Yang， Jing.， et al. AZD1152， a novel and selective aurora B kinase inhibitor， induces growth arrest， apoptosis， and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep 15; 110 (6) :2034-40. [3]. Zekri A， et al. AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy. Tumour Biol. 2015 Feb; 36 (2) :623-32.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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