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Alvespimycin Hydrochloride

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Cat.No：IA1780 Solarbio

CAS：467214-21-7

Molecular Formula：C₃₂H₄₈N₄O₈·HCl

Molecular Weight：653.21

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	467214-21-7
Name	Alvespimycin Hydrochloride
Molecular Formula	C₃₂H₄₈N₄O₈·HCl
Molecular Weight	653.21
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	C/C1=C\C=C/[C@@H]([C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](CC(C(C(NC1=O)=CC2=O)=O)=C2NCCN(C)C)C)OC)O[H])C)OC(N)=O)OC.Cl
Target Point	HSP90
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	Alvesspimycin hydrochloride is a potent Hsp90 inhibitor.
Biological Activity	Alvespimycin hydrochloride 是一种有效的 Hsp90 抑制剂，结合到 Hsp90，EC50 为 62±29 nM[1-3]。
IC50	HSP90:62nM(EC50) GRP94:65nM(EC50)[1-3]
Data Literature Source	[1]. Ge J，et al. Design，synthesis，and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent，water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15. [2]. Hertlein E，et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood. 2010 Jul 8;116(1):45-53. [3]. Henke A，et al. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24;8(9). pii: E77.
Unit	Bottle
Specification	10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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