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Vatalanib dihydrochloride

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Cat.No：IV0390 Solarbio

CAS：212141-51-0

Molecular Formula：C₂₀H₁₅ClN₄·2HCl

Molecular Weight：419.73

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	212141-51-0
Name	Vatalanib dihydrochloride
Molecular Formula	C₂₀H₁₅ClN₄·2HCl
Molecular Weight	419.73
Solubility	Soluble in Water/DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD08458964
SMILES	ClC1=CC=C(C=C1)NC2=NN=C(C3=C2C=CC=C3)CC4=CC=NC=C4.[H]Cl.[H]Cl
Target Point	VEGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK
Background	It is an inhibitor of VEGFR2/KDR.
Biological Activity	Vatalanib是VEGFR2/KDR的抑制剂，其IC50值为37nM。Vatalanib还抑制Flk，c-Kit和PDGFRβ，IC50分别为270 nM，730 nM和580 nM。[1-3]
Data Literature Source	[1]. Wood JM，et al. PTK787/ZK 222584，a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases，impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000，60(8 [2]. Murakami M，et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011，18(2)，589-596. [3]. Wan J，et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35(3):1297-308.
Unit	Bottle
Specification	10mg 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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