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Triciribine

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Cat.No：IT1270 Solarbio

CAS：35943-35-2

Molecular Formula：C₁₃H₁₆N₆O₄

Molecular Weight：320.3

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	35943-35-2
Name	Triciribine
Molecular Formula	C₁₃H₁₆N₆O₄
Molecular Weight	320.3
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00932413
SMILES	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C3=NC=NC4=C3C(C(N)=NN4C)=C2
Target Point	DNA/RNA Synthesis
Passage	Cell Cycle;DNA Damage/DNA Repair
Background	Triciribine is a DNA synthesis inhibitor that also inhibits Akt and HIV-1/2.
Biological Activity	Triciribine 是一种 DNA 合成 (DNA synthesis) 抑制剂，也抑制 Akt 和 HIV-1/2，IC50 分别为 130 nM 和 0.02-0.46 μM。[1-4]
Data Literature Source	[1]. Dieterle A，et al. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Int J Cancer. 2009 Aug 15;125(4):932-41. [2]. Gürsel DB，et al. Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies. Neuro Oncol. 2011 Jun;13(6):610-21. [3]. Kucera LS，et al. Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14. [4]. Abdalla M，et al. The Akt inhibitor，triciribine，ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug;172(16):4173-88.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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