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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Rucaparib phosphateCAS：459868-92-9
Molecular Formula：C19H18FN3O·H3PO4
Molecular Weight：421.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 459868-92-9 |
| Name | Rucaparib phosphate |
| Molecular Formula | C19H18FN3O·H3PO4 |
| Molecular Weight | 421.36 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17010269 |
| SMILES | O=P(O)(O)O.FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1 |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | It is a potent PARP1/2/3 inhibitor. |
| Biological Activity | Rucaparib (AG-014699, PF-01367338)是有效可口服的 PARP1/2/3 抑制剂，结合PARP1的Ki为1.4 nM，对PARP其余亚型也有亲和性。[1-4] |
| Data Literature Source | [1]. Thomas HD，et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther，2007，6(3)，945-956. [2]. Hunter JE，et al. NF-κB mediates radio-sensitization by the PARP-1 inhibitor，AG-014699. Oncogene，2012，31(2)，251-264. [3]. Daniel RA，et al. Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. Br J Cancer，2010，103(10)，1588-1596. [4]. Daniel RA，et al. Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma. Clin Cancer Res，2009，15(4)，1241-1249. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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