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NVP-TAE 684

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Cat.No：IN0800 Solarbio

CAS：761439-42-3

Molecular Formula：C₃₀H₄₀ClN₇O₃S

Molecular Weight：614.2

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	761439-42-3
Name	NVP-TAE 684
Molecular Formula	C₃₀H₄₀ClN₇O₃S
Molecular Weight	614.2
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD11977634
SMILES	O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N5CCN(CC5)C)CC4)C=C3OC)=NC=C2Cl)(C(C)C)=O
Target Point	ALK
Passage	Protein Tyrosine Kinase/RTK;Angiogenesis
Background	NVP-TAE 684 is a potent and selective ALK inhibitor.
Biological Activity	NVP-TAE 684 是一种高效的，选择性的 ALK 抑制剂，阻止 ALCL 衍生的 ALK 依赖性细胞株的生长，IC50 值为 2-10 nM。[1-3]
Data Literature Source	[1]. Galkin AV，et al. Identification of NVP-TAE684，a potent，selective，and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. [2]. Katayama R，et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7535-40. [3]. Schonherr C，Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684. Biochem J. 2011 Dec 15;440(3):405-13
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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