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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > mLN 8054CAS：869363-13-3
Molecular Formula：C25H15ClF2N4O2
Molecular Weight：476.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 869363-13-3 |
| Name | mLN 8054 |
| Molecular Formula | C25H15ClF2N4O2 |
| Molecular Weight | 476.86 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD11840561 |
| SMILES | O=C(C1=CC=C(NC2=NC3=C(CN=C(C4=C3C=CC(Cl)=C4)C5=C(F)C=CC=C5F)C=N2)C=C1)O |
| Target Point | Aurora Kinase |
| Passage | Cell Cycle |
| Background | mLN8054 is a potent and selective Aurora A inhibitor. |
| Biological Activity | MLN8054是高效，选择性，有口服活性的Aurora A 抑制剂，IC50 值为4 nM[1-2]。 |
| IC50 | Aurora A:4nM [1-2] |
| Data Literature Source | [1]. Manfredi MG，et al. Antitumor activity of MLN8054，an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. [2]. Huck JJ，et al. MLN8054，an inhibitor of Aurora A kinase，induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res. 2010 Mar;8(3):373-84. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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