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GSK 690693

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Cat.No：IG1100 Solarbio

CAS：937174-76-0

Molecular Formula：C₂₁H₂₇N₇O₃

Molecular Weight：425.48

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	937174-76-0
Name	GSK 690693
Molecular Formula	C₂₁H₂₇N₇O₃
Molecular Weight	425.48
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD14105605
SMILES	CC(O)(C)C#CC1=NC=C(OC[C@@H]2CNCCC2)C3=C1N=C(C4=NON=C4N)N3CC
Target Point	AMPK;Akt
Passage	PI3K/Akt/mTOR;Epigenetics
Background	GSK-690693 is a broad-spectrum Akt inhibitor.
Biological Activity	GSK-690693 是一种广谱的 Akt 抑制剂，作用于 Akt1/2/3，IC50 值分别为 2/13/9 nM；PKA，PrkX 和 PKC 对其也比较敏感。[1-3]
Data Literature Source	[1]. Rhodes N，et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res，2008，68(7)，2366-2374. [2]. Levy DS，et al. AKT inhibitor，GSK690693，induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood，2009，113(8)，1723-1729. [3]. Altomare DA，et al. GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Clin Cancer Res，2010，16(2)，486-496
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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