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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > ForetinibCAS：849217-64-7
Molecular Formula：C34H34F2N4O6
Molecular Weight：632.65
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 849217-64-7 |
| Name | Foretinib |
| Molecular Formula | C34H34F2N4O6 |
| Molecular Weight | 632.65 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038048 |
| SMILES | O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O |
| Target Point | VEGFR;c-Met;KDR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Foretinib is a multi-targeted tyrosine kinase inhibitor. |
| Biological Activity | Foretinib是一种多靶点酪氨酸激酶抑制剂，抑制 Met 和 KDR 的IC50分别为0.4 nM 和 0.9 nM[1-3]。 |
| IC50 | KDR:0.9nM;c-Met:0.4nM [1-3] |
| Data Literature Source | [1]. Qian F，et al. Inhibition of tumor cell growth，invasion，and metastasis by EXEL-2880 (XL880，GSK1363089)，a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res，2009，69(20)，8009-8016. [2]. Kataoka Y，et al. Foretinib (GSK1363089)，a multi-kinase inhibitor of MET and VEGFRs，inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs，2011. [3]. Eder JP，et al. A phase I study of foretinib，a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res，2010，16(13)，3507-3516 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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