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Danusertib

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Cat.No：ID1070 Solarbio

CAS：827318-97-8

Molecular Formula：C₂₆H₃₀N₆O₃

Molecular Weight：474.55

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	827318-97-8
Name	Danusertib
Molecular Formula	C₂₆H₃₀N₆O₃
Molecular Weight	474.55
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD12024692
SMILES	O=C(N1CC2=C(NN=C2NC(C3=CC=C(N4CCN(CC4)C)C=C3)=O)C1)[C@@H](C5=CC=CC=C5)OC
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Danusertib is an Aurora kinase inhibitor.
Biological Activity	Danusertib 是一种Aurora kinase抑制剂，能够抑制 Aurora A，Aurora B 和 Aurora C 的活性，IC50 值分别为 13，79 和 61 nM[1-3]。
IC50	Aurora A:13nM;Aurora B:79nM;Aurora C:61nM [1-3]
Data Literature Source	[1]. Zi D，et al. Danusertib Induces Apoptosis，Cell Cycle Arrest，and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells. Int J Mol Sci. 2015 Nov 13;16(11):27228-51. [2]. Gontarewicz A，et al. Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I. Blood. 2008 Apr 15;111(8):4355-64. [3]. Fraedrich K，et al. Targeting Aurora Kinases with Danusertib (PHA-739358) Inhibits Growth of Liver Metastases from Gastroenteropancreatic Neuroendocrine Tumors in an Orthotopic Xenograft Model. Clin Cancer Res. 2012 Sep 1;18(17):4621-32. Epub 2012 Jul 2.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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