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Dacinostat

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Cat.No：ID1060 Solarbio

CAS：404951-53-7

Molecular Formula：C₂₂H₂₅N₃O₃

Molecular Weight：379.4522

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	404951-53-7
Name	Dacinostat
Molecular Formula	C₂₂H₂₅N₃O₃
Molecular Weight	379.4522
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00198409
SMILES	O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Dacinostat is a potent HDAC inhibitor.
Biological Activity	Dacinostat 是一种有效的 HDAC 抑制剂，IC50 值为 32 nM；Dacinostat 同时可抑制 HDAC1 的活性，IC50 值为 9 nM，主要用于癌症研究[1-3]。
IC50	HDAC1:9nM;HDAC:32nM [1-3]
Data Literature Source	[1]. Atadja P，et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor，NVP-LAQ824. Cancer Res. 2004 Jan 15;64(2):689-95. [2]. Cho YS，et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem. 2010 Apr 8;53(7):2952-63. [3]. Romanski A，et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11(17):3219-26.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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