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ADL-5859

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Cat.No：IA1730 Solarbio

CAS：850173-95-4

Molecular Formula：C₂₄H₂₈N₂O₃·HCl

Molecular Weight：428.95

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	850173-95-4
Name	ADL-5859
Molecular Formula	C₂₄H₂₈N₂O₃·HCl
Molecular Weight	428.95
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17215194
SMILES	OC1=C2C(OC3(C=C2C4=CC=C(C=C4)C(N(CC)CC)=O)CCNCC3)=CC=C1.Cl
Target Point	Opioid Receptor
Passage	GPCR & G Protein;Neuronal Signaling
Background	ADL5859 is a delta-opioid receptor selective agonist.
Biological Activity	ADL-5859 (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM， respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain[1-2].
IC50	78μM(hERG channel);43μM(CYP2D6)[1-2]
Data Literature Source	[1]. Le Bourdonnec B，et al. Potent，orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N，N-diethyl-4-(5-hydroxyspiro[chromene-2，4'-piperidine]-4-yl)benzamide (ADL5859). J Med Chem. 2008 Oct 9;51(19):5893-6. [2]. Le Bourdonnec B，et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N，N-diethyl-3-hydroxy-4-(spiro[chromene-2，4'-piperidine]-4-yl) benzamide (ADL5747).J Med Chem. 2009 Sep 24;52(18):5685-702.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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