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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AbirateroneCAS：154229-19-3
Molecular Formula：C24H31NO
Molecular Weight：349.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 154229-19-3 |
| Name | Abiraterone |
| Molecular Formula | C24H31NO |
| Molecular Weight | 349.51 |
| Solubility | Soluble in DMSO/Ethanol ≥2mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 810-941-6 |
| MDL | MFCD00924100 |
| SMILES | C[C@@]12C(C3=CN=CC=C3)=CC[C@]1([C@@]4(CC=C5[C@@](C)([C@]4(CC2)[H])CC[C@@H](C5)O)[H])[H] |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Abiraterone is a potent and selective irreversible CYP17 inhibitor. |
| Biological Activity | Abiraterone 是一种有效的选择性的不可逆 CYP17 抑制剂, IC50 为 2 到 4 nM[1]。 |
| IC50 | IC50: 2 to 4nM (CYP17) [1] |
| Data Literature Source | [1]. Attard G， et al. Phase I clinical trial of a selective inhibitor of CYP17， abiraterone acetate， confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008 Oct 1; 26 (28) :4563-71. [2]. Richards J， et al. Interactions of abiraterone， eplerenone， and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1; 72 (9) :2176-82. [3]. Stein MN， et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun; 16 (3) :387-400. [4]. Li R， et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1; 18 (13) :3571-9. [5]. Kumar SV， et al. Validated RP-HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats. Biomed Chromatogr. 2013 Feb; 27 (2) :203-7. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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