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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > ZingeroneCAS：122-48-5
Molecular Formula：C11H14O3
Molecular Weight：194.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 122-48-5 |
| Name | Zingerone |
| Molecular Formula | C11H14O3 |
| Molecular Weight | 194.23 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-548-3 |
| MDL | MFCD00048232 |
| SMILES | COC1=C(O)C=CC(CCC(C)=O)=C1 |
| InChIKey | OJYLAHXKWMRDGS-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3 |
| PubChem CID | 31211 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | It has anti-inflammatory, anti-diabetic, anti-lipid allergic, anti-diarrheal, anti-spasmodic and anti-tumor activities. Can alleviate oxidative stress and inflammation, and downregulate NF-κB-mediated signaling pathways. |
| Biological Activity | Zingerone 是一种无毒的甲氧基苯酚，从生姜中得到，具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤[3]等活性[1]。Zingerone 能够缓解氧化应激和炎症，下调 NF-κB 介导的信号通路[2]。Zingerone 作为抗有丝分裂剂，能够抑制神经母细胞瘤的生长[3]。 |
| Data Literature Source | [1]. Ahmad B，et al. A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone). ScientificWorldJournal. 2015;2015:816364. [2]. Ahmad B，et al. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J. 2018 Dec;26(8):1137-1145. [3]. Choi JS，et al. Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. Int J Mol Sci. 2018 Sep 19;19(9) |
| Unit | Bottle |
| Specification | 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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