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Cabozantinib

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Cat.No：IC1770 Solarbio

CAS：849217-68-1

Molecular Formula：C₂₈H₂₄FN₃O₅

Molecular Weight：501.51

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	849217-68-1
Name	Cabozantinib
Molecular Formula	C₂₈H₂₄FN₃O₅
Molecular Weight	501.51
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 692-846-8
MDL	MFCD20926324
SMILES	O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Target Point	VEGFR;c-Met
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK
Background	Cabozantinib is a potent multi-receptor tyrosine kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3.
Biological Activity	Cabozantinib是一种有效的多受体酪氨酸激酶抑制剂，抑制VEGFR2，c-Met，Kit，Axl 和 Flt3 的 IC50 分别为0.035，1.3，4.6，7 和 11.3 nM[1-3]。
Data Literature Source	[1]. You WK，et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res，2011，71(14)，4758-4768. [2]. Yakes FM，et al. Cabozantinib (XL184)，a novel MET and VEGFR2 inhibitor，simultaneously suppresses metastasis，angiogenesis，and tumor growth. Mol Cancer Ther，2011，10(12)，2298-2308. [3]. Fuse MA，et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398.
Unit	Bottle
Specification	20mg 100mg 200mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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