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Panobinostat

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Cat.No：IP1290 Solarbio

CAS：404950-80-7

Molecular Formula：C₂₁H₂₃N₃O₂

Molecular Weight：349.43

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to brown Solid

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Product Information

CAS	404950-80-7
Name	Panobinostat
Molecular Formula	C₂₁H₂₃N₃O₂
Molecular Weight	349.43
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 803-814-1
MDL	MFCD09833242
SMILES	O=C(/C=C/C1=CC=C(CNCCC2=C(NC3=C2C=CC=C3)C)C=C1)NO
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Panobinostat is a non-selective histone deacetylase (HDAC) inhibitor.
Biological Activity	Panobinostat是一种非选择性组蛋白去乙酰化酶 (HDAC) 抑制剂[1-3]。
Data Literature Source	[1]. Scuto A，et al. The novel histone deacetylase inhibitor，LBH589，induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [2]. Crisanti MC，et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [3]. Ocio EM，et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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