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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > LenalidomideCAS：191732-72-6
Molecular Formula：C13H13N3O3
Molecular Weight：259.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 191732-72-6 |
| Name | Lenalidomide |
| Molecular Formula | C13H13N3O3 |
| Molecular Weight | 259.26 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 691-297-1 |
| MDL | MFCD07772307 |
| SMILES | O=C1C2=CC=CC(N)=C2CN1C(C(N3)=O)CCC3=O |
| Target Point | TNF-α;Ligand for E3 Ligase |
| Passage | Apoptosis;Ubiquitin |
| Background | Lenalidomide is a TNF- α Secretion inhibitor; It is also the ligand of CRBN. It causes the selective ubiquitination and degradation of two lymphoid transcription factors IKZF1 and IKZF3 through CRBN-CRL4 ubiquitin ligase. |
| Biological Activity | Lenalidomide是用作免疫调节药物的 TNF-α 抑制剂。它还具有抗血管生成活性。[1-6] |
| Data Literature Source | [1]. Omran A，et al. Effects of MRP8，LPS，and lenalidomide on the expressions of TNF-α ，brain-enriched，and inflammation-related microRNAs in the primary astrocyte culture. ScientificWorldJournal. 2013 Sep 21;2013:208309. [2]. Kotla V，et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36. [3]. Lopez-Girona A，et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35. [4]. Rozewski DM，et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. AAPS J. 2012 Dec;14(4):872-82. [5]. Minzel W，et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25. [6]. Nagashima，Takeyuki，et al. PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS ACTIVE INGREDIENT. Patent. 20170360780A1 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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