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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > NintedanibCAS：656247-17-5
Molecular Formula：C31H33N5O4
Molecular Weight：539.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 656247-17-5 |
| Name | Nintedanib |
| Molecular Formula | C31H33N5O4 |
| Molecular Weight | 539.63 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD11974012 |
| SMILES | O=C1NC2=CC(C(OC)=O)=CC=C2/C1=C(NC3=CC=C(N(C(CN4CCN(C)CC4)=O)C)C=C3)\C5=CC=CC=C5 |
| Target Point | PDGFR;VEGFR1/2/3;FGFR1/2/3 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Nintedanib is a potent triple angiokinase inhibitor that inhibits VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β. |
| Biological Activity | BIBF 1120是一种有效的三重血管激酶抑制剂，抑制 VEGFR1/2/3，FGFR1/2/3 和 PDGFRα/β 的 IC50 值分别为 34 nM/13 nM/13 nM，69 nM/37 nM/108 nM 和 59 nM/65 nM[1-3]。 |
| Data Literature Source | [1]. Hilberg F，et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res，2008，68(12)，4774-4782. [2]. Roth GJ，et al. Design，synthesis，and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem，2009，52(14)，4466-4480. [3]. Suzuki N，et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine，tipiracil and the novel triple angiokinase inhibitor nintedanib，on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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