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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > CI-1040CAS：212631-79-3
Molecular Formula：C17H14ClF2IN2O2
Molecular Weight：478.66
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 212631-79-3 |
| Name | CI-1040 |
| Molecular Formula | C17H14ClF2IN2O2 |
| Molecular Weight | 478.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02683961 |
| SMILES | O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3 |
| Target Point | MEK |
| Passage | MAPK |
| Background | It is a highly specific small molecule inhibitor of MEK. |
| Biological Activity | CI-1040 是有口服活性，高度特异的MEK小分子抑制剂，对MEK1的IC50值为17 nM [1-3]。 |
| IC50 | MEK1:17nM[1-3] |
| Data Literature Source | [1]. Allen LF，et al. CI-1040 (PD184352)，a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16. [2]. Wei CR，et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20(10):1961-8. [3]. Kramer BW，et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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