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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > BMS-536924CAS：468740-43-4
Molecular Formula：C25H26ClN5O3
Molecular Weight：479.96
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 468740-43-4 |
| Name | BMS-536924 |
| Molecular Formula | C25H26ClN5O3 |
| Molecular Weight | 479.96 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14635360 |
| SMILES | O=C1C(C2=NC3=CC(N4CCOCC4)=CC(C)=C3N2)=C(C=CN1)NC[C@@H](O)C5=CC=CC(Cl)=C5 |
| Target Point | IGF-1R |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor. |
| Biological Activity | BMS-536924 (CS-0117)是一种ATP竞争性的IGF-1R抑制剂，IC50为100 nM，对Mek， Fak，和Lck也具有适中的抑制活性，但对Akt1，和MAPK1/2几乎无抑制活性。[1] |
| IC50 | Insulin Receptor: 73nM;IGF-1R: 100nM[1] |
| Data Literature Source | [1] Wittman M，et al. J Med Chem，2005，48(18)，5639-5643 [2] Litzenburger BC，et al. Clin Cancer Res，2009，15(1)，226-237 [3] Huang F，et al. Cancer Res，2009，69(1)，161-170 [4] Hirokazu Ohashi，et al. Cancer Sci，2012，103(2)，252-261 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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