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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AxitinibCAS：319460-85-0
Molecular Formula：C22H18N4OS
Molecular Weight：386.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to yellow Solid
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| CAS | 319460-85-0 |
| Name | Axitinib |
| Molecular Formula | C22H18N4OS |
| Molecular Weight | 386.47 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 638-771-6 |
| MDL | MFCD09837898 |
| SMILES | O=C(C1=C(SC2=CC3=C(C(/C=C/C4=CC=CC=N4)=NN3)C=C2)C=CC=C1)NC |
| Target Point | VEGFR;PDGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Axitinib is a multi-target tyrosine kinase inhibitor that inhibits VEGFR1， VEGFR2， VEGFR3， and PDGFRβ. |
| Biological Activity | Axitinib是多靶点的酪氨酸激酶抑制剂，抑制 VEGFR1，VEGFR2，VEGFR3， PDGFRβ 的 IC50 值分别为4，20，4，2 nM[1-3]。 |
| IC50 | VEGFR1:0.1nM;VEGFR2:0.2nM;VEGFR3:0.1nM PDGFRβ:1.6nM [1-3] |
| Data Literature Source | [1]. Fenton BM，et al. The addition of AG-013736 to rractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15;67(20):9921-8. [2]. Hu-Lowe DD，et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736)，an oral，potent，and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1，2，3. Clin Cancer Res. 2008 Nov 15;14(22):7272-83 [3]. Allen E，et al. Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 2016 May 10;15(6):1144-60 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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