{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > XAV-939CAS：284028-89-3
Molecular Formula：C14H11F3N2OS
Molecular Weight：312.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 284028-89-3 |
| Name | XAV-939 |
| Molecular Formula | C14H11F3N2OS |
| Molecular Weight | 312.31 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 687-302-1 |
| MDL | MFCD01094205 |
| SMILES | O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1 |
| Target Point | Tankyrase |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | XAV-939 is a tankyrase (TNKS) inhibitor and an indirect Wnt/β-catenin signaling inhibitor. |
| Biological Activity | XAV-939是端锚聚合酶 (tankyrase (TNKS)) 抑制剂，也是间接的 Wnt/β-catenin signaling 抑制剂。抑制 TNKS1 和 TNKS2 的 IC50 分别为 5 和 2 nM。[1-7] |
| Data Literature Source | [1]. Huang SM，et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-620. [2]. Dregalla RC，et al. Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY). 2010 Oct;2(10):691-708. [3]. Ao A，et al. DMH1，a Novel BMP Small Molecule Inhibitor，Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells.，PLoS One. 2012;7(7):e41627. [4]. Zeng L，et al. Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model. Int Immunopharmacol. 2014 Jan;18(1):175-81. [5]. Bai J，et al. Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis. J Immunol. 2015 May 1;194(9):4185-98. doi: 10.4049/jimmunol.1403196. Epub 2015 Mar 30. [6]. Narwal M，et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. [7]. Liu D，et al. Wnt/β-catenin signaling participates in the regulation of lipogenesis in the liver of juvenile turbot (Scophthalmus maximus L.). Comp Biochem Physiol B Biochem Mol Biol. 2016 Jan;191:155-62 |
| Unit | Piece |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
TRIM29 facilitates proliferation and malignancy of cholangiocarcinoma cells by activating MAPK and β-catenin pathways
Click to check >>Author：Jing Yang, Wenqing Bao, Haiyan Diao, Shaofei Yang, Lin Qiu, Chunjing Xu, Bin Zhao
IF：4.1090
Publish_to：ENVIRONMENTAL TOXICOLOGY
PMID：37219039
Manual Download
