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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > VandetanibCAS：443913-73-3
Molecular Formula：C22H24BrFN4O2
Molecular Weight：475.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 443913-73-3 |
| Name | Vandetanib |
| Molecular Formula | C22H24BrFN4O2 |
| Molecular Weight | 475.35 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 669-841-4 |
| MDL | MFCD07772346 |
| SMILES | FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC |
| Target Point | VEGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Vandetanib is a potent VEGFR2 inhibitor. |
| Biological Activity | Vandetanib是有效的 VEGFR2 抑制剂，IC50 为40 nM。Vandetanib抑制VEGFR3和EGFR，IC50分别为110 nM和500 nM。[1-4] |
| Data Literature Source | [1]. Wedge SR，et al. ZD6474 inhibits vascular endothelial growth factor signaling，angiogenesis，and tumor growth following oral administration. Cancer Res. 2002 Aug 15;62(16):4645-55. [2]. Hegedus C，et al. Interaction of the EGFR inhibitors gefitinib，vandetanib，pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. Biochem Pharmacol. 2012 Aug 1;84(3):260-7. [3]. Takeda H，et al. Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency. Exp Cell Res. 2013 Feb 15;319(4):417-23. [4]. Inoue K，et al. Vandetanib，an inhibitor of VEGF receptor-2 and EGF receptor，suppresses tumor development and improves prognosis of liver cancer in mice. Clin Cancer Res. 2012 Jul 15;18(14):3924-33. Vandetanib物理化学性质 |
| Unit | Piece |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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