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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > U0126-EthanolCAS：1173097-76-1
Molecular Formula：C18H16N6S2·C2H6O
Molecular Weight：426.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 1173097-76-1 |
| Name | U0126-Ethanol |
| Molecular Formula | C18H16N6S2·C2H6O |
| Molecular Weight | 426.56 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02101663 |
| SMILES | NC1=CC=CC=C1S/C(N)=C(/C(C#N)=C(SC2=C(C=CC=C2)N)\N)C#N.CCO |
| Target Point | MEK;Autophagy;Mitophagy |
| Passage | MAPK;Autophagy |
| Background | It is a potent, non-ATP-competitive, selective inhibitor of MEK1 and MEK2. It is also an inhibitor of autophagy and mitophagy. |
| Biological Activity | U0126是一种有效, 非ATP竞争性的 MEK1 和 MEK2 抑制剂, IC50 分别为70 nM和60 nM[1-4]。 |
| IC50 | MEK2:60nM (IC50)mEK1:70nM (IC50) [1-4] |
| Data Literature Source | [1]. Duncia JV， et al. MEK inhibitors: the chemistry and biological activity of U0126， its analogs， and cyclization products. Bioorg Med Chem Lett. 1998， 8 (20) ， 2839-2844. [2]. Droebner K， et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011， 92 (2) ， 195-203. [3]. Bessard A， et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11; 27 (40) :5315-25. [4]. Ahnstedt H， et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar; 35 (3) :454-60 |
| Unit | Piece |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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