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PD98059

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Cat.No：IP1200 Solarbio

CAS：167869-21-8

Molecular Formula：C₁₆H₁₃NO₃

Molecular Weight：267.28

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	167869-21-8
Name	PD98059
Molecular Formula	C₁₆H₁₃NO₃
Molecular Weight	267.28
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00671789
SMILES	O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N
InChIKey	QFWCYNPOPKQOKV-UHFFFAOYSA-N
InChI	InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
PubChem CID	4713
Target Point	MEK
Passage	MAPK
Background	PD98059 is a potent and selective MEK1 and MEK2 inhibitor.
Biological Activity	PD98059是有效, 选择性和可渗透细胞的 MEK1 和 MEK2 抑制剂, IC50 分别为4 μM, 50 μM[1-4]。
IC50	MEK:5μM (IC50) [1-4]
Data Literature Source	[1]. Reiners JJ Jr， et al. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Mol Pharmacol. 1998 Mar; 53 (3) :438-45. [2]. Alessi DR， et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem， 1995， 270 (46) ， 27489-27494. [3]. Di Paola R， et al. PD98059， a specific MAP kinase inhibitor， attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice. Pharmacol Res. 2010 Feb; 61 (2) :175-87. [4]. Rojewska E， et al. PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy. PLoS One. 2015 Oct 1; 10 (10) :e0138583.
Unit	Piece
Specification	5mg 10mM*1mL in DMSO 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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