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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Bacterial > Puromycin aminonucleosideCAS：58-60-6
Molecular Formula：C12H18N6O3
Molecular Weight：294.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 58-60-6 |
| Name | Puromycin aminonucleoside |
| Molecular Formula | C12H18N6O3 |
| Molecular Weight | 294.31 |
| Solubility | Soluble in Water/DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-388-3 |
| MDL | MFCD00063462 |
| SMILES | OC[C@@H]1[C@@H](N)[C@H]([C@H](N2C=NC3=C2N=CN=C3N(C)C)O1)O |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
| InChI | InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1 |
| PubChem CID | 6020 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Puromycin aminonucleoside is an aminonucleoside antibiotic that is a puromycin analog, but does not affect protein synthesis or induce apoptosis. |
| Biological Activity | Puromycin aminonucleoside 是一种氨基核苷类抗生素，为嘌呤霉素类似物，但并不影响蛋白质合成或诱导凋亡。[1-4] |
| Data Literature Source | [1]. Wada T，et al. Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol. 2005 Sep;16(9):2615-25. [2]. Xia L，et al. Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleosidenephrotoxicity. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1307-13. [3]. Kawakami H，et al. Dynamics of absolute amount of nephrin in a single podocyte in puromycin aminonucleoside nephrosis rats calculated by quantitative glomerular proteomics approach with selected reaction monitoring mode. Nephrol Dial Transplant. 2012 Apr; [4]. Nosaka K，et al. An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free Radic Biol Med 1997 ;22 (4): 597-605 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mM*1mL in Water 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity
Click to check >>Author：Kong Z;Yin H;Wang F;Liu Z;Luan X;Sun L;Liu W;Shang
IF：7.4600
Publish_to：Plos Pathoges
PMID：35584187
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