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My CartCAS：187227-45-8
Molecular Formula：C14H24N2O4
Molecular Weight：284.35
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 187227-45-8 |
| Name | Oseltamivir acid |
| Molecular Formula | C14H24N2O4 |
| Molecular Weight | 284.35 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00953940 |
| SMILES | O=C(O)C1=C[C@H]([C@@H]([C@H](C1)N)NC(C)=O)OC(CC)CC |
| Target Point | Influenza Virus |
| Passage | Anti-infection |
| Background | Oseltamivir acid is an inhibitor of influenza virus neuraminidase. |
| Biological Activity | Oseltamivir acid，是GS 4071的乙酯前药，是流感病毒神经氨酸酶的抑制剂，IC50 约为100 nM。[1-4] |
| Data Literature Source | [1]. Ferraris O，et al. Sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice. Antiviral Res. 2005 Oct;68(1):43-8. [2]. Gubareva LV，et al. Comparison of the activities of zanamivir，oseltamivir，and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8. [3]. Yen HL，et al. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J Infect Dis. 2005 Aug 15;192(4):665-72. [4]. Hoffmann G，et al. Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61 |
| Unit | Piece |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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