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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > NocodazoleCAS：31430-18-9
Molecular Formula：C14H11N3O3S
Molecular Weight：301.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 31430-18-9 |
| Name | Nocodazole |
| Molecular Formula | C14H11N3O3S |
| Molecular Weight | 301.32 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 250-626-5 |
| MDL | MFCD00005588 |
| SMILES | O=C(OC)NC1=NC2=CC=C(C(C3=CC=CS3)=O)C=C2N1 |
| InChIKey | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19) |
| PubChem CID | 4122 |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Nocodazole is a rapidly reversible microtubule inhibitor. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly kinetics, thereby preventing mitosis and inducing tumor cell apoptosis. |
| Biological Activity | Nocodazole是快速可逆的 microtubule 抑制剂。 Nocodazole与β-微管蛋白结合并破坏微管组装/拆卸动力学，从而防止有丝分裂并诱导肿瘤细胞凋亡[1-6]。 |
| Data Literature Source | [1]. Park H，et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL，c-KIT，BRAF，and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6. [2]. Keliang Xu，et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002 [3]. Long BH，et al. Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res. 1994 Aug 15;54(16):4355-61. [4]. Wang YJ，et al. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210. [5]. Signoretto E，et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92. [6]. Zhang JP，et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35. |
| Unit | Piece |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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